The House Hotel Bosphorus consists of 26 rooms and suites in a 5-storey, 19th-century Ottoman mansion at the foot of the Bosphorus Bridge, as well as The Mansion, containing a suite and two rooms. The hotel is in the lively and vibrant, cobblestoned enclave of Ortaköy, home to a famous mosque as well as a range of restaurants, cafes and clubs.

The historic building is the former home of Ottoman-era architect Simon Balian, a member of the Armenian family behind many of Istanbul's landmark imperial buildings, including the Dolmabahçe and Çırağan palaces. The hotel was designed by The House Hotel's signature Turkish collaborators, Autoban, combining historical glamour with contemporary design. The Bosphorus Lounge offers a stunning view stretching from the bridge to the Topkapı Palace, serving buffet breakfast, snacks and drinks, or guests can head to sister establishment The House Café on the ground floor. There is also a small gym. The hotel is conveniently located on the main shore road, and offers a private boat - The House Boat - for guests, including airport transfers.